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Science Mar 29, 2025

Pulsatile flow induces chromatin interaction with lamin-associated proteins to enrich H3K9 methylation in endothelial cells

Proceedings of the National Academy of Sciences, Volume 122, Issue 12, March 2025.
SignificanceThis study reveals the mechanism by which mechanical forces such as shear stress regulate vascular inflammation. We demonstrate that PS induces a specific epigenetic landscape characterized by the enrichment of H3K9 trimethylation at the ...

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